Since the beginning of the 2000s, the team at the MAR & Gen clinic developed several treatment protocols to improve the quality of the oocytes of women with problems.
In 2005, a team led by Dr. Jan Tesarik and Dr. Carmen Mendoza published a study, in the scientific journal Human Reproduction, that shows that the administration of growth hormone during ovarian stimulation improves the probability of delivery of a healthy child in women over 40 years of age. Later, the same team has shown that growth hormone also improves the results of assisted reproduction in some young women with poor oocyte quality, especially those suffering from polycystic ovarian syndrome.
The use of powerful antioxidants, such as melatonin and coenzyme Q10, improves oocyte quality in certain women, especially those with endometriosis or overweight.
The MARGen clinic team has summarized their findings on the effects of different antioxidants on oocyte quality in an article published in 2021 in the International Journal of Molecular Sciences.